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Evolutionary biclustering of gene expressions

Ubiquity, Volume 2006 Issue October | BY Haider Banka , Sushmita Mitra 


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With the advent of microarray technology it has been possible to measure thousands of expression values of genes in a single experiment. Biclustering or simultaneous clustering of both genes and conditions is challenging particularly for the analysis of high-dimensional gene expression data in information retrieval, knowledge discovery, and data mining. The objective here is to find sub-matrices, i.e., maximal subgroups of genes and subgroups of conditions where the genes exhibit highly correlated activities over a range of conditions while maximizing the volume simultaneously. Since these two objectives are mutually conflicting, they become suitable candidates for multi-objective modeling. In this study, we will describe some recent literature on biclustering as well as a multi-objective evolutionary biclustering framework for gene expression data along with the experimental results.

[This article is available as a PDF only. It originally appeared on Ubiquity, Volume 7, Issue 42 (October 31, 2006 - November 6, 2006).]


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